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Bremelanotide acetate
CAS No. 1607799-13-2
Bremelanotide acetate( PT-141 acetate )
Catalog No. M12310 CAS No. 1607799-13-2
Bremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH; melanocortin receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 41 | Get Quote |
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| 25MG | 75 | Get Quote |
|
| 50MG | 125 | Get Quote |
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| 100MG | 186 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBremelanotide acetate
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NoteResearch use only, not for human use.
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Brief DescriptionBremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH; melanocortin receptor agonist.
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DescriptionBremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH; melanocortin receptor agonist.Sexual Dysfunction Phase 3 Clinical(In Vivo):Bremelanotide Acetate (50-200 μg/kg; s.c.; once) significantly increases proceptive solicitations in females primed with Estradiol benzoate+Progesterone or Estradiol benzoate alone in bilevel chambers.
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In Vitro——
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In VivoBremelanotide Acetate (50-200 μg/kg; s.c.; once) significantly increases proceptive solicitations in females primed with Estradiol benzoate+Progesterone or Estradiol benzoate alone in bilevel chambers. Animal Model:Ovariectomized Long–Evans rats Dosage:50, 100, 200 μg/kg Administration:s.c.; once Result:Significantly increased proceptive solicitations in females primed with Estradiol benzoate+Progesterone or Estradiol benzoate alone in bilevel chambers.
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SynonymsPT-141 acetate
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research AreaEndocrinology
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IndicationSexual Dysfunction
Chemical Information
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CAS Number1607799-13-2
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Formula Weight1085.215
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Molecular FormulaC52H72N14O12
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 36 mg/mL
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SMILESCCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C.CC(=O)O
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Chemical Name(3S,6S,9R,12S,15S,23S)-12-((1H-imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((S)-2-acetamidohexanamido)-9-benzyl-6-(3-guanidinopropyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid with acetic acid (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Neuropeptide EI, rat
Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.
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HS 024
Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
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HS 014
Potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
