AKT Kinase Inhibitor( —— )

Catalog No. M16130 CAS No. 842148-40-7

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Product Name

AKT Kinase Inhibitor
Note

Research use only, not for human use.
Brief Description

An Akt kinase inhibitor.
Description

An Akt kinase inhibitor.
In Vitro

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied.Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
In Vivo

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt
Research Area

Cancer
Indication

——

CAS Number

842148-40-7
Formula Weight

357.3672
Molecular Formula

C16H19N7O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N
Chemical Name

2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-