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A-674563 hydrochloride
CAS No. ——
A-674563 hydrochloride( A 674563 hydrochloride | A674563 hydrochloride )
Catalog No. M17012 CAS No. ——
A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameA-674563 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
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DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1); increases the efficacy of paclitaxel in a PC-3 xenograft model; enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway; also suppresses FLT3-ITD positive AML both in vitro and in vivo.
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In Vitro——
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In Vivo——
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SynonymsA 674563 hydrochloride | A674563 hydrochloride
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight——
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Molecular FormulaC22H23ClN4O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILES——
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Chemical Name(S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
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