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AKT-IN-6
CAS No. 1430056-54-4
AKT-IN-6( —— )
Catalog No. M34828 CAS No. 1430056-54-4
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | 788 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAKT-IN-6
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NoteResearch use only, not for human use.
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Brief DescriptionAKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli.
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DescriptionAKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
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In VitroAkt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number1430056-54-4
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Formula Weight389.43
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Molecular FormulaC22H20FN5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (320.98 mM; Ultrasonic )
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SMILESCn1ncc(C#N)c1-c1ccc2C(=O)N(Cc2c1)[C@H](CN)Cc1cccc(F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
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