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AA-861

CAS No. 80809-81-0

AA-861( Docebenone )

Catalog No. M16020 CAS No. 80809-81-0

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AA-861
  • Note
    Research use only, not for human use.
  • Brief Description
    AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.
  • Description
    AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM; induces cytotoxic and anti-proliferative effects in 5-LO-positive Capan-2 pancreatic cancer cells; also efficiently inhibits biofilms by preventing the formation of amyloid-like fibers.Allergy Discontinued.
  • In Vitro
    Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently.
  • In Vivo
    Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M.
  • Synonyms
    Docebenone
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    Lipoxygenase
  • Research Area
    Inflammation/Immunology
  • Indication
    Allergy

Chemical Information

  • CAS Number
    80809-81-0
  • Formula Weight
    326.436
  • Molecular Formula
    C21H26O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (765.86 mM)
  • SMILES
    O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O
  • Chemical Name
    2-(12-hydroxydodeca-5,10-diynyl)- 3,5,6-trimethyl-p-benzoquinone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Romero D, et al. Chem Biol. 2013 Jan 24;20(1):102-10. 2. Yoshimoto T, et al. Biochim Biophys Acta. 1982 Nov 12;713(2):470-3. 3. Fischer AS, et al. Br J Pharmacol. 2010 Oct;161(4):936-49.
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