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Home - Products - Membrane Transporter/Ion Channel - Chloride Channel - T16Ainh-A01

T16Ainh-A01

CAS No. 552309-42-9

T16Ainh-A01( —— )

Catalog No. M14998 CAS No. 552309-42-9

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 75 In Stock
5MG 58 In Stock
10MG 93 In Stock
25MG 183 In Stock
50MG 274 In Stock
100MG 417 In Stock
200MG 603 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    T16Ainh-A01
  • Note
    Research use only, not for human use.
  • Brief Description
    T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A.
  • Description
    T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM; T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl ) channels and whole cell currents activated by 500 nM free Ca2+; T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve; blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    552309-42-9
  • Formula Weight
    416.514
  • Molecular Formula
    C19H20N4O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (200.06 mM)
  • SMILES
    CCC1=C(N=C(NC1=O)SCC(=O)NC2=NC(=CS2)C3=CC=C(C=C3)OC)C
  • Chemical Name
    2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Davis AJ, et al. Br J Pharmacol. 2013 Feb;168(3):773-84. 2. Mazzone A, et al. Biochem Biophys Res Commun. 2012 Oct 19;427(2):248-53. 3. Forrest AS, Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1229-43. 4. Namkung W, et al. J Biol Chem. 2011 Jan 21;286(3):2365-74.
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