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Home - Products - Membrane Transporter/Ion Channel - Chloride Channel - T16Ainh-A01

T16Ainh-A01

CAS No. 552309-42-9

T16Ainh-A01( —— )

Catalog No. M14998 CAS No. 552309-42-9

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    T16Ainh-A01
  • Note
    Research use only, not for human use.
  • Brief Description
    T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A.
  • Description
    T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM; T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl ) channels and whole cell currents activated by 500 nM free Ca2+; T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve; blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    552309-42-9
  • Formula Weight
    416.514
  • Molecular Formula
    C19H20N4O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (200.06 mM)
  • SMILES
    CCC1=C(N=C(NC1=O)SCC(=O)NC2=NC(=CS2)C3=CC=C(C=C3)OC)C
  • Chemical Name
    2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Davis AJ, et al. Br J Pharmacol. 2013 Feb;168(3):773-84. 2. Mazzone A, et al. Biochem Biophys Res Commun. 2012 Oct 19;427(2):248-53. 3. Forrest AS, Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1229-43. 4. Namkung W, et al. J Biol Chem. 2011 Jan 21;286(3):2365-74.
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