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DRAinh-A250

CAS No. 858747-13-4

DRAinh-A250( DRAinhA250 | DRAinh A250 | DRAinh-A250 )

Catalog No. M16225 CAS No. 858747-13-4

DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    DRAinh-A250
  • Note
    Research use only, not for human use.
  • Brief Description
    DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA).
  • Description
    DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM; does not inhibit the homologous anion exchangers SLC26A4 (pendrin) or SLC26A6 (PAT-1), as well as other related proteins or intestinal ion channels; blocked fluid absorption in closed colonic loops but not in jejunal loops in mice, while the NHE3 (SLC9A3) inhibitor tenapanor blocked absorption only in the jejunum; reduces signs of constipation in loperamide-treated mice after oral treatment.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DRAinhA250 | DRAinh A250 | DRAinh-A250
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    858747-13-4
  • Formula Weight
    417.255
  • Molecular Formula
    C20H17BrO5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)CC(C1=O)=C(C)C2=C(O1)C(C)=C(OCC3=CC=CC(Br)=C3)C=C2
  • Chemical Name
    2-(7-((3-bromobenzyl)oxy)-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Haggie PM, et al. JCI Insight. 2018 Jul 26;3(14). pii: 121370.
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