Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - Chloride Channel - IAA-94

IAA-94

CAS No. 54197-31-8

IAA-94( IAA94 )

Catalog No. M14941 CAS No. 54197-31-8

IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
2MG 29 In Stock
5MG 52 In Stock
10MG 85 In Stock
25MG 161 In Stock
50MG 276 In Stock
100MG 408 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    IAA-94
  • Note
    Research use only, not for human use.
  • Brief Description
    IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.
  • Description
    IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM; significantly suppresses IGF-I-induced VSMC proliferation, also blocks cell swelling evoked glutamate release from primary microglia and MLS-9 cells; effectively reduces IFNgamma-induced NO production in microglial BV2 cells.
  • In Vitro
    IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins.
  • In Vivo
    ——
  • Synonyms
    IAA94
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    54197-31-8
  • Formula Weight
    357.2284
  • Molecular Formula
    C17H18Cl2O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3
  • Chemical Name
    Acetic acid, 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Landry DW, et al. J Gen Physiol. 1987 Dec;90(6):779-98. 2. Cheng G, et al. Cardiovasc Res. 2007 Jan 1;73(1):198-207. 3. Schlichter LC, et al. Channels (Austin). 2011 Mar-Apr;5(2):128-37. 4. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • DRAinh-A250

    DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA).

  • NS1652

    NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.NS1652 (20 μM) fully and reversibly inhibits the red cell Cl-conductance. NS1652 effectively inhibits the chloride conductance (IC50, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC50, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production (IC50: 3.1 μM in BV2 cells).

  • Irisolidone

    Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.

Sign In Join Free