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Home - Products - GPCR/G Protein - Neurokinin Receptor - Ibodutant

Ibodutant

CAS No. 522664-63-7

Ibodutant( MEN-15596 | MEN 15596 )

Catalog No. M14847 CAS No. 522664-63-7

A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ibodutant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).
  • Description
    A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6); induces a concentration-dependent rightward shift of the [βAla(8)]NKA(4-10) concentration-response curves without depressing the maximal contractile effect (3-100 nM); shows good in vivo activity after intravenous, intraduodenal, and oral administration in guinea pigs.Irritable Bowel Syndrome Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MEN-15596 | MEN 15596
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    Neurokinin Receptor
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    522664-63-7
  • Formula Weight
    644.866
  • Molecular Formula
    C37H48N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC2=CC=C(C)C=C2S1)NC3(C(N[C@H](CC4=CC=CC=C4)C(NCC5CCN(CC6CCOCC6)CC5)=O)=O)CCCC3
  • Chemical Name
    6-methyl-N-(1-(((R)-1-oxo-3-phenyl-1-(((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)amino)propan-2-yl)carbamoyl)cyclopentyl)-2,3-dihydrobenzo[b]thiophene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meini S, et al. J Pharmacol Exp Ther. 2009 May;329(2):486-95. 2. Fedi V, et al. J Med Chem. 2007 Oct 4;50(20):4793-807. 3. Santicioli P, et al. Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7.
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