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Vofopitant dihydrochloride

CAS No. 168266-51-1

Vofopitant dihydrochloride( —— )

Catalog No. M33169 CAS No. 168266-51-1

Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 261 In Stock
5MG 235 In Stock
10MG 376 In Stock
25MG 712 In Stock
50MG 1042 In Stock
100MG 1423 In Stock
200MG Get Quote In Stock
500MG 2762 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Vofopitant dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.
  • Description
    Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively,acts as a potential broad-spectrum anti-emetic agent.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    Neurokinin receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    168266-51-1
  • Formula Weight
    505.36
  • Molecular Formula
    C21H25Cl2F3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 33.33 mg/mL (65.95 mM; Ultrasonic) DMSO : 33.33 mg/mL (65.95 mM; Ultrasonic )
  • SMILES
    Cl.Cl.COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)-n1nnnc1C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.?
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