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Vofopitant dihydrochloride
CAS No. 168266-51-1
Vofopitant dihydrochloride( —— )
Catalog No. M33169 CAS No. 168266-51-1
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 261 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 376 | In Stock |
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| 25MG | 712 | In Stock |
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| 50MG | 1042 | In Stock |
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| 100MG | 1423 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2762 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVofopitant dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionVofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.
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DescriptionVofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively,acts as a potential broad-spectrum anti-emetic agent.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNeurokinin receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number168266-51-1
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Formula Weight505.36
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Molecular FormulaC21H25Cl2F3N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 33.33 mg/mL (65.95 mM; Ultrasonic) DMSO : 33.33 mg/mL (65.95 mM; Ultrasonic )
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SMILESCl.Cl.COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)-n1nnnc1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Eledoisin
Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994.
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Neurokinin A(4-10)
Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle.
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Vapreotide acetate
Vapreotide acetate is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
