DC_517( DC-517 )

Catalog No. M14673 CAS No. 500017-70-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DC_517
Note

Research use only, not for human use.
Brief Description

DC_05 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM.
Description

DC_05 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases; significantly inhibits cancer cell proliferation in vitro.
In Vitro

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells.
In Vivo

——
Synonyms

DC-517
Pathway

Chromatin/Epigenetic
Target

DNMT
Recptor

DNMT
Research Area

Cancer
Indication

——

CAS Number

500017-70-9
Formula Weight

505.6499
Molecular Formula

C33H35N3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

OC(CNC(C)C)COC(CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CN4C5=C(C6=C4C=CC=C6)C=CC=C5
Chemical Name

2-Propanol, 1-[2-(9H-carbazol-9-yl)-1-(9H-carbazol-9-ylmethyl)ethoxy]-3-[(1-methylethyl)amino]-

1. Chen S, et al. J Med Chem. 2014 Nov 13;57(21):9028-41.

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