MC3343( MC-3343 | MC 3343 )

Catalog No. M12164 CAS No. 1535187-91-7

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HNMR

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MSDS

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Product Name

MC3343
Note

Research use only, not for human use.
Brief Description

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.
Description

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively; displays increased potency against DNMT1 compared with RG-108 and SGI-1027; efficiently inhibits OS cell proliferation and induces osteoblastic differentiation, induces dose- and time-dependent decreases in DNMT1, DNMT3a and DNMT3b protein levels in Saos-2 OS cells; displays synergistic effects with doxorubicin and cisplatin in vivo, reduces patient-derived xenograft OS growth and induces differentiation.
In Vitro

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In Vivo

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Synonyms

MC-3343 | MC 3343
Pathway

Chromatin/Epigenetic
Target

DNMT
Recptor

DNMT
Research Area

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Indication

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CAS Number

1535187-91-7
Formula Weight

461.529
Molecular Formula

C27H23N7O
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=CC(=NC(=N1)N)NC2=CC(=CC=C2)NC(=O)C3=CC(=CC=C3)NC4=CC=NC5=CC=CC=C54
Chemical Name

N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide

1. Manara MC, et al. Mol Cancer Ther. 2018 Jun 29. pii: molcanther.0818.2017.

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