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SGI-1027
CAS No. 1020149-73-8
SGI-1027( SGI1027 | SGI 1027 )
Catalog No. M10094 CAS No. 1020149-73-8
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 90 | In Stock |
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| 25MG | 158 | In Stock |
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| 50MG | 290 | In Stock |
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| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1014 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSGI-1027
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NoteResearch use only, not for human use.
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Brief DescriptionSGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B.
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DescriptionSGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B; induces selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B in different cancer cell lines.
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In Vitro——
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In Vivo——
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SynonymsSGI1027 | SGI 1027
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PathwayChromatin/Epigenetic
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TargetDNMT
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RecptorDNMT1|DNMT3A|DNMT3B
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1020149-73-8
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Formula Weight461.5178
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Molecular FormulaC27H23N7O
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Purity>98% (HPLC)
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SolubilityDMSO: 27 mg/mL
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SMILESO=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3
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Chemical NameBenzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Datta J, et al. Cancer Res. 2009 May 15;69(10):4277-85.
2. Rilova E, et al. ChemMedChem. 2014 Mar;9(3):590-601.
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