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ASP 9853
CAS No. 442198-67-6
ASP 9853( ASP9853 | ASP-9853 | FR 260330 dehydrate )
Catalog No. M14503 CAS No. 442198-67-6
A potent, orally active iNOS inhibitor that prevents dimerization of iNOS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 459 | In Stock |
|
| 10MG | 657 | In Stock |
|
| 25MG | 1026 | In Stock |
|
| 50MG | 1386 | In Stock |
|
| 100MG | 1832 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 3655 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameASP 9853
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active iNOS inhibitor that prevents dimerization of iNOS.
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DescriptionA potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.Blood Cancer Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsASP9853 | ASP-9853 | FR 260330 dehydrate
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number442198-67-6
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Formula Weight617.026
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Molecular FormulaC29H28ClF3N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN(CCC1OC2=NC=NC(=C2)C(F)(F)F)C(=O)CNC(=O)C(CC3=CC=CC=N3)NC(=O)C=CC4=CC=C(C=C4)Cl
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Chemical Name(S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58.
2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.
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