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GW-766994 R-form
CAS No. 408303-44-6
GW-766994 R-form( —— )
Catalog No. M14405 CAS No. 408303-44-6
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGW-766994 R-form
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NoteResearch use only, not for human use.
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Brief DescriptionGW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
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DescriptionGW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number408303-44-6
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Formula Weight451.348
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Molecular FormulaC21H24Cl2N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.
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