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RS-102895 hydrochloride
CAS No. 1173022-16-6
RS-102895 hydrochloride( RS102895 hydrochloride )
Catalog No. M10577 CAS No. 1173022-16-6
A potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | Get Quote |
|
| 5MG | 54 | Get Quote |
|
| 10MG | 81 | Get Quote |
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| 25MG | 170 | Get Quote |
|
| 50MG | 303 | Get Quote |
|
| 100MG | 455 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRS-102895 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3.
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DescriptionA potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17 uM); inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM; significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).
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In Vitro——
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In Vivo——
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SynonymsRS102895 hydrochloride
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1173022-16-6
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Formula Weight426.8598
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Molecular FormulaC21H22ClF3N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESO=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1.Cl
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Chemical NameSpiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18;275(33):25562-71.
2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57.
3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22;10:11.
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