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Pyrvinium pamoate
CAS No. 3546-41-6
Pyrvinium pamoate( Pyrvinium embonate )
Catalog No. M14210 CAS No. 3546-41-6
An anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 61 | In Stock |
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| 50MG | 75 | In Stock |
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| 100MG | 112 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePyrvinium pamoate
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NoteResearch use only, not for human use.
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Brief DescriptionAn anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM.
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DescriptionAn anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM; binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
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In Vitro——
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In Vivo——
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SynonymsPyrvinium embonate
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorCasein Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number3546-41-6
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Formula Weight575.7
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Molecular FormulaC26H28N3 . 1/2 C23H14O6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 24 mg/mL
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SMILESCN(C)C1=CC2=C([N+](C)=C(/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3)C=C2)C=C1.CN(C)C5=CC6=C([N+](C)=C(/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7)C=C6)C=C5.[O-]C(C9=CC%10=C(C=CC=C%10)C(CC%11=C(O)C(C([O-])=O)=CC%12=C%11C=CC=C%12)=C9O)=O
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Chemical NameQuinolinium, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.
2. Li B, et al. Cancer Res. 2014 Sep 1;74(17):4811-21.
3. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
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