Bendamustine hydrochloride

Research use only, not for human use.

Bendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.

Bendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.(In Vitro):Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.(In Vivo):Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.

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SDX-105

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis

Cancer

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3543-75-7

394.72

C16H21Cl2N3O2·HCl

>98% (HPLC)

Ethanol: 17 mg/mL (43.06 mM); Water: 2 mg/mL (5.06 mM); DMSO: 78 mg/mL (197.6 mM)

Cl.CN1C(CCCC(O)=O)=NC2=C1C=CC(=C2)N(CCCl)CCCl

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(-20℃)

With Ice Pack

≥ 2 years