Bendamustine hydrochloride
CAS No. 3543-75-7
Bendamustine hydrochloride( SDX-105 )
Catalog No. M14207 CAS No. 3543-75-7
Bendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 25MG | 41 | In Stock |
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| 50MG | 65 | In Stock |
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| 100MG | 117 | In Stock |
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| 200MG | 201 | In Stock |
|
| 500MG | 337 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBendamustine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.
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DescriptionBendamustine hydrochloride is an alkylating agent associated with DNA damage with IC50 of 50 μM.(In Vitro):Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.(In Vivo):Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.
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In Vitro——
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In Vivo——
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SynonymsSDX-105
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA synthesis
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number3543-75-7
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Formula Weight394.72
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Molecular FormulaC16H21Cl2N3O2·HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 17 mg/mL (43.06 mM); Water: 2 mg/mL (5.06 mM); DMSO: 78 mg/mL (197.6 mM)
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SMILESCl.CN1C(CCCC(O)=O)=NC2=C1C=CC(=C2)N(CCCl)CCCl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Leoni LM, et al. Clin Y Res. 2008, 14(1), 309-317.
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