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L82-G17
CAS No. 92285-87-5
L82-G17( —— )
Catalog No. M28986 CAS No. 92285-87-5
L82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 375 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | 724 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL82-G17
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NoteResearch use only, not for human use.
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Brief DescriptionL82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
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DescriptionL82-G17 is an uncompetitive LigI-selective inhibitor in human cells with utility as a probe of the catalytic activity and cellular functions of LigI.
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In VitroL82-G17 (200 μM, 30 min) has selective uncompetitive inhibitory effect for LigI. L82-G17 (0-100 μM) increases LigI binding to non-ligatable nicked DNA binding.L82-G17 inhibits step 3 of the ligation reaction, phosphodiester bond formation.L82-G17 (0-100 μM) inhibits DNA synthesis, cell viability and s induces DNA damage. Cell Viability Assay Cell Line:HeLa cells Concentration:0-30 μM Incubation Time:5 days Result:Reduced cell number by about 70% at 20 μM.Cell Proliferation Assay Cell Line:CH12F3 WT and CH12F3Δ/Δ cells Concentration:0-100 μM Incubation Time:72 h Result:Had great effect on the proliferation and survival of the parental CH12F3 cells.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorFGFR2
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Research Area——
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Indication——
Chemical Information
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CAS Number92285-87-5
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Formula Weight264.67
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Molecular FormulaC11H9ClN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (472.29 mM)
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SMILESOC1=CC=CC(\C=N\NC2=C(Cl)C(=O)NN=C2)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CX-5461
CX-5461 is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I.
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CCG-203971
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.
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HALOFUGINONE LACTATE
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.
