DIMATE( —— )

Catalog No. M14196 CAS No. 350229-29-7

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

DIMATE
Note

Research use only, not for human use.
Brief Description

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor.
Description

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM; shows selective cytotoxicity in leukemic population enriched in LSCs, with no cytotoxicity for healthy hematopoietic stem cells; promotes the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in xenograft mouse models.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

ALDH
Recptor

ALDH
Research Area

——
Indication

——

Chemical Information

CAS Number

350229-29-7
Formula Weight

185.285
Molecular Formula

C9H15NOS
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pérez-Alea M, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.160. 2. Venton, et al. Blood Cancer J. 2016 Sep 9;6(9):e469. 3. Quash G, et al. Eur J Med Chem. 2008 May;43(5):906-16.

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