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WIN-18446
CAS No. 1477-57-2
WIN-18446( WIN18446 | WIN 18446 )
Catalog No. M12038 CAS No. 1477-57-2
A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 25MG | 32 | In Stock |
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| 50MG | 45 | In Stock |
|
| 100MG | 68 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 164 | In Stock |
|
| 1G | 244 | In Stock |
|
Biological Information
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Product NameWIN-18446
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.
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DescriptionA potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM; potently inhibits spermatogenesis and causes infertility in vivo by inhibiting retinoic acid synthesis.
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In VitroRT-PCR Cell Line:Testes were collected from 2-dpp mice.Concentration:1 μM.Incubation Time:24 h.Result:Results in a VAD-like phenotype in the testis.Alone or in combination with ROL significantly reduced Stra8 expression.
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In VivoAnimal Model:Six-month-old male New Zealand white rabbits.Dosage:200 mg/kg.Administration:Orally for 4, 8, and 16 weeks.Result:Resulted in marked suppression of testicular weight over time.Dramatically suppressed spermatogenesis.Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
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SynonymsWIN18446 | WIN 18446
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PathwayMetabolic Enzyme/Protease
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TargetALDH
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RecptorALDH
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Research Area——
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Indication——
Chemical Information
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CAS Number1477-57-2
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Formula Weight366.11
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Molecular FormulaC12H20Cl4N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (273.14 mM)
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SMILESC(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl
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Chemical NameN,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Amory JK, et al. J Androl. 2011 Jan-Feb;32(1):111-9.
2. Paik J, et al. J Biol Chem. 2014 May 23;289(21):15104-17.
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