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SANT-1
CAS No. 304909-07-7
SANT-1( SANT-1 | SANT 1 | SANT1 )
Catalog No. M13967 CAS No. 304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 193 | In Stock |
|
| 100MG | 343 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSANT-1
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NoteResearch use only, not for human use.
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Brief DescriptionSANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
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DescriptionSANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
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In VitroCell Viability Assay Cell Line:Medulloblastoma cells Concentration:1 μM Incubation Time:24 hours or 48 hours Result:Inhibited cellular proliferation in primary tumorspheres.
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In Vivo——
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SynonymsSANT-1 | SANT 1 | SANT1
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorSmoothened
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number304909-07-7
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Formula Weight373.49
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Molecular FormulaC23H27N5
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL (53.54 mM); DMSO: 21 mg/mL (56.22 mM)
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SMILESCC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4
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Chemical NameN-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. James K. Chen, et al. Proc natl Acad Sci U S A, 2002, 99(22), 14071-14076.
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