SANT-1( SANT-1 | SANT 1 | SANT1 )

Catalog No. M13967 CAS No. 304909-07-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

SANT-1
Note

Research use only, not for human use.
Brief Description

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
Description

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
In Vitro

Cell Viability Assay Cell Line:Medulloblastoma cells Concentration:1 μM Incubation Time:24 hours or 48 hours Result:Inhibited cellular proliferation in primary tumorspheres.
In Vivo

——
Synonyms

SANT-1 | SANT 1 | SANT1
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Smoothened
Research Area

Cancer
Indication

——

CAS Number

304909-07-7
Formula Weight

373.49
Molecular Formula

C23H27N5
Purity

>98% (HPLC)
Solubility

Ethanol: 20 mg/mL (53.54 mM); DMSO: 21 mg/mL (56.22 mM)
SMILES

CC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C)=NN1C4=CC=CC=C4
Chemical Name

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

1. James K. Chen, et al. Proc natl Acad Sci U S A, 2002, 99(22), 14071-14076.

Calculator

molnova catalog