Pepstatin( NSC 272671 | Pepsin Inhibitor S 735A )

Catalog No. M13803 CAS No. 26305-03-3

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HNMR

HPLC

MSDS

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Product Name

Pepstatin
Note

Research use only, not for human use.
Brief Description

Pepstatin is a potent inhibitor of aspartyl proteases; inhibits the aspartic proteases cathepsin D, pepsin, and renin.
Description

Pepstatin is a potent inhibitor of aspartyl proteases; inhibits the aspartic proteases cathepsin D, pepsin, and renin.
In Vitro

——
In Vivo

Animal Model:Pylorus ligated male Wistar rats Dosage:0.5, 1, 10 and 50 mg/kg Administration:Oral administration, 15 minutes after pyloric ligation Result:Effectively prevented stomach ulceration.
Synonyms

NSC 272671 | Pepsin Inhibitor S 735A
Pathway

Immunology/Inflammation
Target

Amino Acids and Derivatives
Recptor

aspartic protease
Research Area

Cancer
Indication

——

CAS Number

26305-03-3
Formula Weight

685.89
Molecular Formula

C34H63N5O9
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL (145.79 mM)
SMILES

C[C@@H](CC([C@H](C(C)C)NC(CC(C)C)=O)=O)[C@@H](C(N)=O)N[C@@H](CC(C)C)C(O)CC(NC(C)C(NC([C@@H](O)CC(O)=O)CC(C)C)=O)=O
Chemical Name

(3S,12S,14S,15S,18S)-14-carbamoyl-3,11-dihydroxy-4,12-diisobutyl-18-isopropyl-7,15,22-trimethyl-6,9,17,20-tetraoxo-5,8,13,19-tetraazatricosanoic acid

1.Seelmeier S, et al. Proc Natl Acad Sci U S A. 1988, 85(18), 6612-6616.

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