Revexepride( SSP 002358 | SPD-557 )

Catalog No. M13507 CAS No. 219984-49-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Revexepride
Note

Research use only, not for human use.
Brief Description

Revexepride (SSP 002358;SPD-557) potent, highly selective 5-HT4 receptor agonist for the treatment of gastroesophageal reflux disease.
Description

Revexepride (SSP 002358;SPD-557) potent, highly selective 5-HT4 receptor agonist for the treatment of gastroesophageal reflux disease. Other Indication Phase 2 Discontinued.
In Vitro

The human CYP isoenzymes are involved in the metabolism of revexepride, which is mainly metabolized in vitro in humans by CYP3A4 (99.9%) with a minor contribution of CYP2D6 (0.1%). Revexepride exhibits direct inhibition of human CYP3A4 in vitro with IC50 values of 16-49 μM.
In Vivo

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Synonyms

SSP 002358 | SPD-557
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

219984-49-3
Formula Weight

425.954
Molecular Formula

C21H32ClN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 100 mg/mL (234.77 mM)
SMILES

O=C(C1=CC(Cl)=C(N)C2=C1OC(C)(C)C2)NC[C@H]3[C@H](O)CN(CCCOC)CC3
Chemical Name

4-amino-5-chloro-N-(((3S,4S)-3-hydroxy-1-(3-methoxypropyl)piperidin-4-yl)methyl)-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamide

1. Flach S, et al. Drug Des Devel Ther. 2016 Sep 27;10:3125-3132. 2. Shaheen NJ, et al. Aliment Pharmacol Ther. 2015 Apr;41(7):649-61.

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