BCX-1470( BCX 1470 | BCX1470 )

Catalog No. M13470 CAS No. 217099-43-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

BCX-1470
Note

Research use only, not for human use.
Brief Description

BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
Description

BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM); displays 3.4-fold and 200-fold bette than that of trypsin, respectively; inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively); blocks the reverse passive Arthus (RPA) reaction in rats.Thrombosis Phase 1 Discontinued.
In Vitro

BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
In Vivo

——
Synonyms

BCX 1470 | BCX1470
Pathway

Immunology/Inflammation
Target

Complement System
Recptor

Complement System
Research Area

Cardiovascular Disease
Indication

Thrombosis

CAS Number

217099-43-9
Formula Weight

302.3714
Molecular Formula

C14H10N2O2S2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1=CSC(=C1)C(=O)OC2=CC3=C(C=C2)C=C(S3)C(=N)N
Chemical Name

2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester

1. Szalai AJ, et al. J Immunol. 2000 Jan 1;164(1):463-8. 2. Babu, Y. S, et al. Patent No. WO 98/55471.

Calculator

molnova catalog