PMX 53 acetate(219639-75-5 free base)( —— )

Catalog No. M37923 CAS No. 852629-88-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PMX 53 acetate(219639-75-5 free base)
Note

Research use only, not for human use.
Brief Description

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively.
Description

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).
In Vitro

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In Vivo

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Synonyms

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Pathway

Immunology/Inflammation
Target

Complement System
Recptor

Complement System
Research Area

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Indication

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CAS Number

852629-88-0
Formula Weight

956.16
Molecular Formula

C49H69N11O9
Purity

>98% (HPLC)
Solubility

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SMILES

N=C(N)NCCC[C@@H]1NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@@H](CC4CCCCC4)NC([C@H]5N(C([C@H](CCCNC1=O)NC([C@H](CC6=CC=CC=C6)NC(C)=O)=O)=O)CCC5)=O)=O)=O.CC(O)=O
Chemical Name

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