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6-Hydroxy-DL-DOPA
CAS No. 21373-30-8
6-Hydroxy-DL-DOPA( 6-Hydroxy-DL-DOPA )
Catalog No. M13405 CAS No. 21373-30-8
6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 101 | In Stock |
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| 10MG | 161 | In Stock |
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| 25MG | 326 | In Stock |
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| 50MG | 510 | In Stock |
|
| 100MG | 768 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name6-Hydroxy-DL-DOPA
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NoteResearch use only, not for human use.
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Brief Description6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
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Description6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM; inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells; also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.
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In Vitro6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937.
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In Vivo——
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Synonyms6-Hydroxy-DL-DOPA
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PathwayCell Cycle/DNA Damage
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TargetDNA Repair Protein
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RecptorDNA Repair Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number21373-30-8
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Formula Weight213.189
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Molecular FormulaC9H11NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (234.53 mM)
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SMILESNC(CC1=CC(O)=C(O)C=C1O)C(O)=O
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Chemical NameAlanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chandramouly G, et al. Chem Biol. 2015 Nov 19;22(11):1491-1504.
2. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740.
3. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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