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Home - Products - Cell Cycle/DNA Damage - DNA Repair Protein - 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA

CAS No. 21373-30-8

6-Hydroxy-DL-DOPA( 6-Hydroxy-DL-DOPA )

Catalog No. M13405 CAS No. 21373-30-8

6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    6-Hydroxy-DL-DOPA
  • Note
    Research use only, not for human use.
  • Brief Description
    6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
  • Description
    6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM; inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells; also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.
  • In Vitro
    6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937.
  • In Vivo
    ——
  • Synonyms
    6-Hydroxy-DL-DOPA
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Repair Protein
  • Recptor
    DNA Repair Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    21373-30-8
  • Formula Weight
    213.189
  • Molecular Formula
    C9H11NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (234.53 mM)
  • SMILES
    NC(CC1=CC(O)=C(O)C=C1O)C(O)=O
  • Chemical Name
    Alanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chandramouly G, et al. Chem Biol. 2015 Nov 19;22(11):1491-1504. 2. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740. 3. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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