MM-589( MM 589 | MM589 )

Catalog No. M13312 CAS No. 2097887-21-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-589
Note

Research use only, not for human use.
Brief Description

A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
Description

A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM; inhibits the MLL H3K4 methyltransferase activity (IC50=12.7 nM), potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations, and shows >40-fold better than MM-401.
In Vitro

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In Vivo

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Synonyms

MM 589 | MM589
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

2097887-21-1
Formula Weight

686.734
Molecular Formula

C30H45F3N8O7
Purity

>98% (HPLC)
Solubility

——
SMILES

CCC1C(=O)NC(C(=O)NCCC(C(=O)NC(C(=O)N1)CCCNC(=NC)N)(C)NC(=O)C(C)C)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
Chemical Name

N-((3R,6S,9S,12R)-6-ethyl-12-methyl-9-(3-(3-methylguanidino)propyl)-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl)isobutyramide 2,2,2-trifluoroacetate

1. Karatas H, et al. J Med Chem. 2017 Jun 22;60(12):4818-4839.

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