WDR5 WIN site inhibitor C6( —— )

Catalog No. M17068 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

WDR5 WIN site inhibitor C6
Note

Research use only, not for human use.
Brief Description

WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM.
Description

WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM; inhibits leukemia cell lines in vitro (MV4:11 cell GI50=3.2 uM), rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

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CAS Number

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Formula Weight

498.383
Molecular Formula

C25H22Cl2FN5O
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

N-(3,4-dichlorobenzyl)-3-(6-fluoro-2-methylpyridin-3-yl)-5-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.

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