NPD13668( NPD-13668 | NPD 13668 )

Catalog No. M16274 CAS No. 864819-54-5

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HNMR

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Product Name

NPD13668
Note

Research use only, not for human use.
Brief Description

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
Description

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels; reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification; effectively suppressed the cell growth of solid tumors even without EZH2 active mutations; inhibits cell proliferation in many cancer cells (PC3 cell IC50=5.39 uM); NPD13668 is a potential modulator of EZH2 methyltransferase activity.
In Vitro

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In Vivo

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Synonyms

NPD-13668 | NPD 13668
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

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CAS Number

864819-54-5
Formula Weight

392.411
Molecular Formula

C22H20N2O5
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=C(C(=O)OC2=C1C=CC(=C2O)O)CC(=O)NCCC3=CNC4=CC=CC=C43
Chemical Name

N-(2-(1H-indol-3-yl)ethyl)-2-(7,8-dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide

1. Murashima A, et al. J Biochem. 2019 Jan 25. doi: 10.1093/jb/mvz007.

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