Deltasonamide 1( Deltasonamide1 )

Catalog No. M13257 CAS No. 2088485-33-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Deltasonamide 1
Note

Research use only, not for human use.
Brief Description

A novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM.
Description

A novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM; inhibits PDE6δ/KRas interaction in cells with Kd of 85 nM, selectively inhibits growth of KRas mutated and -dependent cells.
In Vitro

Cell Proliferation Assay Cell Line:RTCA of hPDAC cell lines.Concentration:0.375, 0.75, 1.5, 3, 6, 12 μM.Incubation Time:60 h.Result:Inhibited proliferation of human pancreatic cancer cell lines.
In Vivo

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Synonyms

Deltasonamide1
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

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Indication

——

CAS Number

2088485-33-8
Formula Weight

647.25
Molecular Formula

C30H39ClN6O4S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 66.67 mg/mL (103.01 mM)
SMILES

O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O
Chemical Name

N1-(4-chlorobenzyl)-N1-cyclopentyl-N4-((2-(methylamino)pyrimidin-4-yl)methyl)-N4-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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