KBFM123

Research use only, not for human use.

KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras.

KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM); interacts directly with a hydrophobic pocket located between Switch I and Switch II and allosterically inhibits the effector interaction by inducing conformational changes in Switch I and its flanking region in the β2-strand, which are directly involved in recognition of the effector molecules including c-Raf-1; KBFM123 is a promising scaffold for the development of Ras inhibitors.

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KBFM-123

MAPK/ERK Signaling

Ras

Ras

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1090346-46-5

271.316

C16H17NO3

>98% (HPLC)

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C1CC(OC1)CNC(=O)C2=CC3=CC=CC=C3C=C2O

3-hydroxy-N-((tetrahydrofuran-2-yl)methyl)-2-naphthamide

(-20℃)

With Ice Pack

≥ 2 years