DAPT ( GSI-IX )

Catalog No. M13243 CAS No. 208255-80-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DAPT
Note

Research use only, not for human use.
Brief Description

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
Description

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
In Vitro

DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts.DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons.
In Vivo

——
Synonyms

GSI-IX
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

γ secretase(Aβ)
Research Area

Neurological Disease
Indication

——

CAS Number

208255-80-5
Formula Weight

432.46
Molecular Formula

C23H26F2N2O4
Purity

>98% (HPLC)
Solubility

Ethanol: 50 mg/mL (115.61 mM); DMSO: 86 mg/mL (198.86 mM)
SMILES

O=C(OC(C)(C)C)[C@H](C1=CC=CC=C1)NC([C@H](C)NC(CC2=CC(F)=CC(F)=C2)=O)=O
Chemical Name

tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate

1.Dovey HF, et al. J Neurochem. 2001, 76(1), 173-18

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