ACO1

CAS No. 2065198-79-8

ACO1( ACO 1 )

Catalog No. M13211 CAS No. 2065198-79-8

ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ACO1
  • Note
    Research use only, not for human use.
  • Brief Description
    ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM.
  • Description
    ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms; exhibits a significant decrease in mutatnt myocilin I477N levels at 30 uM in tetracycline inducible HEK cells; inhibits the migration of MDA-MB-231 and PC-3 MM-2 at 10 uM and 5 uM,respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ACO 1
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2065198-79-8
  • Formula Weight
    405.498
  • Molecular Formula
    C24H27N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-(2-(2-hydroxybenzyl)-1H-pyrrol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mishra SJ, et al. ACS Chem Biol. 2017 Jan 20;12(1):244-253.
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