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Col 003

CAS No. 328565-16-8

Col 003( Col003 )

Catalog No. M14076 CAS No. 328565-16-8

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	61	In Stock
2MG	37	In Stock
5MG	61	In Stock
10MG	104	In Stock
25MG	217	In Stock
50MG	343	In Stock
100MG	531	In Stock
200MG	762	In Stock
500MG	1144	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Col 003
Note

Research use only, not for human use.
Brief Description

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.
Description

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47; competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.
In Vitro

Western Blot Analysis Cell Line:Wild-type MEFs Concentration:100 μM Incubation Time:After 50 °C or 37 °C for 15 min Result:Affected correctly folded triple helix structures and α,α′-dipyridyl on collagen secretion.
In Vivo

——
Synonyms

Col003
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

——
Indication

——

Chemical Information

CAS Number

328565-16-8
Formula Weight

257.245
Molecular Formula

C14H11NO4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (194.37 mM)
SMILES

C1=CC=C(C=C1)CC2=CC(=C(C(=C2)[N+](=O)[O-])O)C=O
Chemical Name

5-benzyl-2-hydroxy-3-nitrobenzaldehyde

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085.

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