Cart
sales@molnova.com
Col 003
CAS No. 328565-16-8
Col 003( Col003 )
Catalog No. M14076 CAS No. 328565-16-8
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
|
| 2MG | 37 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 104 | In Stock |
|
| 25MG | 217 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 531 | In Stock |
|
| 200MG | 762 | In Stock |
|
| 500MG | 1144 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCol 003
-
NoteResearch use only, not for human use.
-
Brief DescriptionCol 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.
-
DescriptionCol 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47; competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.
-
In VitroWestern Blot Analysis Cell Line:Wild-type MEFs Concentration:100 μM Incubation Time:After 50 °C or 37 °C for 15 min Result:Affected correctly folded triple helix structures and α,α′-dipyridyl on collagen secretion.
-
In Vivo——
-
SynonymsCol003
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetHSP
-
RecptorHSP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number328565-16-8
-
Formula Weight257.245
-
Molecular FormulaC14H11NO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (194.37 mM)
-
SMILESC1=CC=C(C=C1)CC2=CC(=C(C(=C2)[N+](=O)[O-])O)C=O
-
Chemical Name5-benzyl-2-hydroxy-3-nitrobenzaldehyde
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
molnova catalog
related products
-
TRC-051384
A potent heat shock protein 70 (HSP70) inducer.
-
Ganetespib
Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.
-
ITZ-1
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
