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KU675
CAS No. 1535221-75-0
KU675( KU-675 | KU 675 )
Catalog No. M12166 CAS No. 1535221-75-0
A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameKU675
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.
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DescriptionA novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively; also displays binding to Hsc70 with Kd of 76.3 uM, reduces the expression of Hsc70-specific client proteins; demonstrates antiproliferative effect against PC3MM2 cells with IC50 of 5-10 uM, for LNCap-LN3, LAPC-4, and C4-2 cells, IC50 if 1.5-2.5 uM; exhibits greater inhibition of Hsp90’s protein folding function than the N-terminal inhibitor, 17-AAG.
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In Vitro——
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In Vivo——
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SynonymsKU-675 | KU 675
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1535221-75-0
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Formula Weight455.939
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Molecular FormulaC24H26ClN3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C=CC2=C1OC(=O)C(=C2)NC(=O)NC3=CC=C(C=C3)Cl)OCCC4CCCCN4
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Chemical Name1-(4-chlorophenyl)-3-(8-methyl-2-oxo-7-(2-(piperidin-2-yl)ethoxy)-2H-chromen-3-yl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu W, et al. Mol Pharmacol. 2015 Jul;88(1):121-30.
2. Burlison JA, et al. J Org Chem. 2008 Mar 21;73(6):2130-7.
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