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ALX-5407 hydrochloride
CAS No. 200006-08-2
ALX-5407 hydrochloride( ALX5407 )
Catalog No. M13122 CAS No. 200006-08-2
ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameALX-5407 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
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DescriptionALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM; has little or no activity at the GlyT2 transporter, at other binding sites for glycine, or at other neurotransmitter transporters; increases free glycine levels in rat prefrontal cortex (10 mg/kg, p.o.).Schizophrenia Discontinued.
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In Vitro——
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In Vivo——
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SynonymsALX5407
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PathwayMembrane Transporter/Ion Channel
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TargetGlyT
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RecptorGlyT
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number200006-08-2
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Formula Weight429.916
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Molecular FormulaC24H25ClFNO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.61 mM)
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SMILESCN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
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Chemical NameN-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Atkinson BN, et al. Mol Pharmacol. 2001 Dec;60(6):1414-20.
2. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.
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