PF-03463275( PF 3463275 )

Catalog No. M10582 CAS No. 1173177-11-1

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Product Name

PF-03463275
Note

Research use only, not for human use.
Brief Description

PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
Description

PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM; shows no significant affinity for GlyT2 (Ki >1 mM); is under investigation for the treatment of schizophrenia.Schizophrenia Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

PF 3463275
Pathway

Membrane Transporter/Ion Channel
Target

GlyT
Recptor

GlyT
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

1173177-11-1
Formula Weight

376.86
Molecular Formula

C19H22ClFN4O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CN(C)C=N1)N(CC2=CC=C(F)C(Cl)=C2)CC3[C@@]4([H])CN(C)C[C@@]34[H]
Chemical Name

N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide

1. Roberts BM, et al. Neuroreport. 2010 Mar 31;21(5):390-4. 2. Liu CN, et al. Cutan Ocul Toxicol. 2014 Sep;33(3):206-11.

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