Chiglitazar( CS-038 | CS038 )

Catalog No. M13073 CAS No. 1959588-75-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Chiglitazar
Note

Research use only, not for human use.
Brief Description

Chiglitazar (CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively.
Description

Chiglitazar (CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively; inhibited alanine gluconeogenesis, lowered the hepatic glycogen level in MSG obese rats. Like rosiglitazone, chiglitazar promoted the differentiation of adipocytes and decreased the maximal diameter of adipocytes; Chiglitazar reduced plasma triglyceride, total cholesterol (TCHO), nonesterified fatty acids (NEFA) and low density lipoprotein-cholesterol levels; lowered hepatic triglyceride and TCHO contents; decreased muscular NEFA level. Unlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARα, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats.Diabetes Phase 3 Clinical.
In Vitro

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In Vivo

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Synonyms

CS-038 | CS038
Pathway

Metabolic Enzyme/Protease
Target

PPAR
Recptor

PPAR
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1959588-75-0
Formula Weight

594.618
Molecular Formula

C36H28FN2NaO4
Purity

>98% (HPLC)
Solubility

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SMILES

C1=CC=C2C(=C1)C3=CC=CC=C3N2CCOC4=CC=C(C=C4)CC(C(=O)[O-])NC5=CC=CC=C5C(=O)C6=CC=C(C=C6)F.[Na+]
Chemical Name

3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)-2-((2-(4-fluorobenzoyl)phenyl)amino)propanoic acid sodium salt

1. Li PP, et al. Br J Pharmacol. 2006 Jul;148(5):610-8. 2. He BK, et al. PPAR Res. 2012;2012:546548. 3. Pan DS, et al. PPAR Res. 2017;2017:4313561.

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