KYA-1797K( KYA 1797K )

Catalog No. M13063 CAS No. 1956356-56-1

COA

Datasheet

HNMR

HPLC

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Product Name

KYA-1797K
Note

Research use only, not for human use.
Brief Description

A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
Description

A derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling; dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM; more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells; binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM; suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).
In Vitro

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In Vivo

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Synonyms

KYA 1797K
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Wnt/β-catenin
Research Area

Cancer
Indication

——

CAS Number

1956356-56-1
Formula Weight

442.501
Molecular Formula

C17H11KN2O6S2
Purity

>98% (HPLC)
Solubility

Ethanol: <1 mg/mL; DMSO: 20 mg/mL (45.2 mM); Water: 20 mg/mL (45.2 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C([O-])CCN(C/1=O)C(SC1=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=S.[K+]
Chemical Name

potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate

1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600. 2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.

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