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CCT-031374
CAS No. 442535-46-8
CCT-031374( CCT031374 )
Catalog No. M14506 CAS No. 442535-46-8
CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCCT-031374
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NoteResearch use only, not for human use.
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Brief DescriptionCCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
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DescriptionCCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.
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In Vitro——
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In Vivo——
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SynonymsCCT031374
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number442535-46-8
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Formula Weight353.425
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Molecular FormulaC23H19N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN2C3=CC=CC=C3N(C2=N1)CC(=O)C4=CC=C(C=C4)C5=CC=CC=C5.Br
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Chemical Name1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73.
2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91.
3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.
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