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GNE-781
CAS No. 1936422-33-1
GNE-781( GNE781 | GNE 781 )
Catalog No. M13035 CAS No. 1936422-33-1
GNE-781 (GNE781) is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 342 | In Stock |
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| 5MG | 297 | In Stock |
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| 10MG | 485 | In Stock |
|
| 25MG | 808 | In Stock |
|
| 50MG | 1070 | In Stock |
|
| 100MG | 1451 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-781
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-781 (GNE781) is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor.
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DescriptionGNE-781 (GNE781) is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays; exhibits high selectivity over BRD4 (1) (>5 uM) and other BRDs; suppresses Myc transcript levels in cellular assays with EC50 of 6.6 nM; displays antitumor activity in an AML tumor model and decreases Foxp3 transcript levels in a dose dependent manner.
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In Vitro——
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In Vivo——
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SynonymsGNE781 | GNE 781
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1936422-33-1
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Formula Weight525.605
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Molecular FormulaC27H33F2N7O2
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 190.26 mM
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SMILESO=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC
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Chemical Name3-[7-(Difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Romero FA, et al. J Med Chem. 2017 Nov 22;60(22):9162-9183.
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