CPI-637( CPI637 | CPI 637 )

Catalog No. M12946 CAS No. 1884712-47-3

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Product Name

CPI-637
Note

Research use only, not for human use.
Brief Description

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
Description

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM; displays >700-fold selectivity over the BET bromodomains (BRD4 IC50=11.0 uM), also highly selective against other bromodomains; inhibits the expression of MYC with an EC50 of 0.60 uM in a cellular assay.(In Vitro):CPI-637 (Compound 28) inhibits MYC expression in AMO-1 cells (EC50 value of 0.60 μM) .
In Vitro

——
In Vivo

——
Synonyms

CPI637 | CPI 637
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD4|CBP|EP300
Research Area

Cancer
Indication

——

CAS Number

1884712-47-3
Formula Weight

386.4497
Molecular Formula

C22H22N6O
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

CN(N=C1C2=CN(C)N=C2)C3=C1C=C(C4=CC=CC(N5)=C4N[C@H](C)CC5=O)C=C3
Chemical Name

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-

1. Taylor AM, et al. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.

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