CeMMEC13( CeMMEC 13 )

Catalog No. M12696 CAS No. 1790895-25-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CeMMEC13
Note

Research use only, not for human use.
Brief Description

A selective TAF1 second bromodomain inhibitor with IC50 of 2.1 uM.
Description

A selective TAF1 second bromodomain inhibitor with IC50 of 2.1 uM; shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.
In Vitro

CeMMEC13 is a potent inhibitor of TAF1 (2) bromodomain, with an IC50 of 2.1 μM. CeMMEC13 shows little or no effects on REDNESS, BRD4, CREBBP. CeMMEC13 (0-20 μM) in combination with (S)-JQ1 increases RFP expression in REDS3 cells and is effective reducing the viability of H23 and THP1 cells, better than that of single treatment.
In Vivo

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Synonyms

CeMMEC 13
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

TAF1
Research Area

Other Indications
Indication

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CAS Number

1790895-25-8
Formula Weight

336.3
Molecular Formula

C19H16N2O4
Purity

>98% (HPLC)
Solubility

DMSO: 62 mg/mL (184.3 mM); Ethanol: 6 mg/mL (17.83 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1=CC(N(C)C2=C1C=CC=C2)=O)NC3=CC=C(OCCO4)C4=C3
Chemical Name

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide

1. Sdelci S, et al. Nat Chem Biol. 2016 Jul;12(7):504-10.

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