PF-CBP1( PF CBP1 )

Catalog No. M13078 CAS No. 1962928-21-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-CBP1
Note

Research use only, not for human use.
Brief Description

A potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively.
Description

A potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively; displays >100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins; reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages, also suppresses the expression of RGS4 in primary cortical neurons.
In Vitro

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors.
In Vivo

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Synonyms

PF CBP1
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

CREB
Research Area

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Indication

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CAS Number

1962928-21-7
Formula Weight

488.6
Molecular Formula

C29H36N4O3
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C
Chemical Name

4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine

1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96.

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