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Home - Products - Metabolic Enzyme/Protease - MMP - CTS-1027

CTS-1027

CAS No. 193022-04-7

CTS-1027( RS-130830 | Ro-1130830 | CTS1027 | CTS-1027 | RS130830 | Ro1130830 )

Catalog No. M13024 CAS No. 193022-04-7

A potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CTS-1027
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14.
  • Description
    A potent, selective, broad-spectrum MMP inhibitor with Ki of <9 nM for MMP2, 3, 8, 9, 12, 13 and 14, but not MMP1 and 7; displays little or no activity for other proteinases including caspases, the initiator and effector proteinases of apoptosis; attenuates hepatocyte apoptosis, liver injury and hepatic fibrosis, and is an attractive agent as a potential hepato-protective agent in HCV patients.HCV Infection Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RS-130830 | Ro-1130830 | CTS1027 | CTS-1027 | RS130830 | Ro1130830
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MMP
  • Recptor
    MMP
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    193022-04-7
  • Formula Weight
    425.8832
  • Molecular Formula
    C19H20ClNO6S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    c1cc(ccc1Oc2ccc(cc2)Cl)S(=O)(=O)CC3(CCOCC3)C(=O)NO
  • Chemical Name
    2H-Pyran-4-carboxamide, 4-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-N-hydroxy-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kahraman A, et al. Hepatol Res. 2009 Aug;39(8):805-13. 2. Liechti FD, et al. J Neuroinflammation. 2015 Mar 4;12:43.
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