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Marimastat
CAS No. 154039-60-8
Marimastat( BB-2516 | TA-2516 )
Catalog No. M12177 CAS No. 154039-60-8
A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 218 | In Stock |
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| 50MG | 355 | In Stock |
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| 100MG | 523 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMarimastat
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NoteResearch use only, not for human use.
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Brief DescriptionA broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.
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DescriptionA broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.Lung Cancer Phase 3 Clinical(In Vitro):Marimastat (BB2516) (1 μM) shows inhibition of vascular outgrowth, and selectively affects angiogenesis.(In Vivo):Animals receiving chemoradiation + Marimastat (BB2516) (8.7 mg/kg) have statistically significant delayed growth, compared to animals receiving chemoradiation alone. Marimastat (BB2516) may work in combination with chemotherapy and radiation to inhibit tumor growth.
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In Vitro——
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In Vivo——
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SynonymsBB-2516 | TA-2516
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorMMP-1| MMP-14| MMP-2| MMP-7| MMP-9
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number154039-60-8
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Formula Weight331.4079
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Molecular FormulaC15H29N3O5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 140 mg/mL
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SMILESO=C(N[C@@H](C(C)(C)C)C(NC)=O)[C@H](CC(C)C)[C@H](O)C(NO)=O
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Chemical NameButanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rasmussen HS, et al. Pharmacol Ther. 1997;75(1):69-75.
2. Sinno M, et al. Stem Cells Dev. 2013 Feb 1;22(3):345-58.
3. Quemener C, et al. Cancer Res. 2007 Jan 1;67(1):9-15.
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