Cart
sales@molnova.com
Marimastat
CAS No. 154039-60-8
Marimastat( BB-2516 | TA-2516 )
Catalog No. M12177 CAS No. 154039-60-8
A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
|
| 5MG | 81 | In Stock |
|
| 10MG | 123 | In Stock |
|
| 25MG | 218 | In Stock |
|
| 50MG | 355 | In Stock |
|
| 100MG | 523 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMarimastat
-
NoteResearch use only, not for human use.
-
Brief DescriptionA broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.
-
DescriptionA broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.Lung Cancer Phase 3 Clinical(In Vitro):Marimastat (BB2516) (1 μM) shows inhibition of vascular outgrowth, and selectively affects angiogenesis.(In Vivo):Animals receiving chemoradiation + Marimastat (BB2516) (8.7 mg/kg) have statistically significant delayed growth, compared to animals receiving chemoradiation alone. Marimastat (BB2516) may work in combination with chemotherapy and radiation to inhibit tumor growth.
-
In Vitro——
-
In Vivo——
-
SynonymsBB-2516 | TA-2516
-
PathwayMetabolic Enzyme/Protease
-
TargetMMP
-
RecptorMMP-1| MMP-14| MMP-2| MMP-7| MMP-9
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number154039-60-8
-
Formula Weight331.4079
-
Molecular FormulaC15H29N3O5
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 140 mg/mL
-
SMILESO=C(N[C@@H](C(C)(C)C)C(NC)=O)[C@H](CC(C)C)[C@H](O)C(NO)=O
-
Chemical NameButanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rasmussen HS, et al. Pharmacol Ther. 1997;75(1):69-75.
2. Sinno M, et al. Stem Cells Dev. 2013 Feb 1;22(3):345-58.
3. Quemener C, et al. Cancer Res. 2007 Jan 1;67(1):9-15.
molnova catalog
related products
-
Incyclinide
Incyclinide is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis.
-
Calycosin-7-O-beta-D...
Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycosin 7-O-β-D-glucoside is anticipated to be a promising anti-HIV agent.
-
TAPI 0
ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.
