REDX-05358( REDX 05358 | REDX05358 )

Catalog No. M12942 CAS No. 1884226-20-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

REDX-05358
Note

Research use only, not for human use.
Brief Description

REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor.
Description

REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively; denmonstrates high selectivity profile against a panel of 468 kinases, exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers; not only inhibits MAPK signalling in BRAF V600E mutant tumor cells, but also in those harbouring NRAS and KRAS mutations; exhibits in vivo efficacy in BRAF V600E CRC xenograft model.
In Vitro

——
In Vivo

——
Synonyms

REDX 05358 | REDX05358
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

Raf
Research Area

——
Indication

——

CAS Number

1884226-20-3
Formula Weight

472.929
Molecular Formula

C26H21ClN4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : < 0.1 mg/mL (insoluble))
SMILES

O=C(CC1)NC2=C1C(OC3=CC(CC(C4=NC=C(C5=CC=CC=C5Cl)N4)CO6)=C6C=C3)=CC=N2
Chemical Name

5-[[3-[5-(2-Chlorophenyl)-1H-imidazol-2-yl]chroman-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one

1. Helen Mason, et al. AACR, Abstract 5160.

Calculator

molnova catalog