Dabrafenib Mesylate( GSK2118436 Mesylate,GSK 2118436B )

Catalog No. M22046 CAS No. 1195768-06-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dabrafenib Mesylate
Note

Research use only, not for human use.
Brief Description

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Description

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM).
In Vitro

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In Vivo

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Synonyms

GSK2118436 Mesylate,GSK 2118436B
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

Raf
Research Area

Cancer
Indication

Low Grade Glioma (LGG) of Brain With BRAF AberrationHigh Grade Glioma (HGG) of the Brain With BRAF AberrationLow Grade Glioma of Brain With Neurofibromatosis Type 1

CAS Number

1195768-06-9
Formula Weight

615.67
Molecular Formula

C24H24F3N5O5S3
Purity

>98% (HPLC)
Solubility

DMSO:34 mg/mL (55.22 mM)
SMILES

CS(O)(=O)=O.CC(C)(C)C1=NC(=C(S1)C1=NC(N)=NC=C1)C1=C(F)C(NS(=O)(=O)C2=C(F)C=CC=C2F)=CC=C1
Chemical Name

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1. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9.

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