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Home - Products - Chromatin/Epigenetic - DNMT - AA-CW236

AA-CW236

CAS No. 1869921-96-9

AA-CW236( AA-CW-236 | AA-CW 236 )

Catalog No. M12892 CAS No. 1869921-96-9

A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AA-CW236
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
  • Description
    A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AA-CW-236 | AA-CW 236
  • Pathway
    Chromatin/Epigenetic
  • Target
    DNMT
  • Recptor
    DNMT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1869921-96-9
  • Formula Weight
    400.786
  • Molecular Formula
    C17H16ClF3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(CCN2N=NC(C3=CC=C(OC(F)(F)F)C=C3)=C2CCl)C(C)=NO1
  • Chemical Name
    4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5.
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